Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR
نویسندگان
چکیده
منابع مشابه
Bdnf Val66met Polymorphism Modulates Sleep Intensity
335 BDNF Genotype and Sleep Intensity—Bachmann et al Moreover, in adult rats, the degree of exploratory behavior predicts the level of BDNF as well as of SWA during subsequent sleep.10 Finally, pharmacological experiments such as injections of exogenous BDNF, an anti-BDNF antibody, and an inhibitor of tyrosine kinase B receptor, the high-affinity BDNF receptor, consistently suggest that this re...
متن کاملDesigning and Validation of One-Step T-ARMS-PCR for Genotyping the eNOS rs1799983 SNP
Background: The transversion of G to T (G894T) in human endothelial nitric oxide synthase (eNOS) gene has profound effects such as male infertility, recurrent miscarriage, multiple sclerosis and cardiovascular diseases.Objectives: Development of a new Multiplex Tetra-Primer Amplifi cation Refractory Mutation System - Polymerase Chain Reaction (T-ARMS-PCR) for detection of...
متن کاملAssociation between the BDNF Val66Met Polymorphism and Chronicity of Depression
OBJECTIVE Both clinical and biological factors influence the course of depressive disorders. This study tested for associations between the brain-derived neurotrophic factor (BDNF) gene at the Val66Met locus and the course of major depressive disorder (MDD). METHODS Three hundred ten Korean subjects (209 patients, 101 controls) were genotyped for rs6265 at nucleotide 196 (G/A), which produces...
متن کاملThe brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans.
The hypothesis that brain-derived neurotrophic factor (BDNF) is involved in the pathogenesis of major depression is supported by several research findings; however, genetic studies assessing the relationship between BDNF and psychiatric disorders have produced conflicting results. We examined the effect of a BDNF polymorphism on depression susceptibility in Mexican-Americans. The single nucleot...
متن کاملVariant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory.
Brain-derived neurotrophic factor (BDNF) plays important roles in activity-dependent plasticity processes, such as long-term potentiation, learning, and memory. The recently reported human BDNF Val66Met (BDNF(Met)) polymorphism has been shown to lead to altered hippocampal volume and impaired hippocampal-dependent memory and is associated with a variety of neuropsychiatric disorders. There are ...
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ژورنال
عنوان ژورنال: Psychiatric Genetics
سال: 2010
ISSN: 0955-8829
DOI: 10.1097/ypg.0b013e32833a2038